STUDIES ON A COMPLEMENT FIXATION TEST FOR HERPES SIMPLEX

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Studies on a complement fixation test for Herpes simplex.

Although the neutralization test is, in general, satisfactory for immunologic studies with a diversity of viruses, it is cumbersome and expensive. The complement fixation test, in contrast, is simple and rapid and has been successfully applied to a number of viral diseases, especially for diagnostic purposes. In the case of herpes simplex virus infections, however, the literature concerning the...

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A Complement Fixation Test for Herpes Simplex Infections.

The serological diagnosis of virus infections depends for the most part on neutralization and complement fixation tests. Both of these have been described in the case of herpes simplex infections, but the neutralization test is used almost exclusively at present, owing to the conflicting results obtained by complement fixation. The reports in the literature on this subject are at variance with ...

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The complement-fixation test in the diagnosis of herpes simplex infections.

As infection with herpes simplex virus appears to be more common than was formerly supposed, laboratory confirmation of the role of this virus in lesions of the mouth, central nervous system, skin, and liver is being sought more often. The simplest laboratory method for diagnosis is by the complement-fixation test, and a number of different methods of making antigen have been recommended since ...

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Confirmation of herpes simplex virus type 2 infections in herpes-like genital lesions by a simple complement-fixation test.

The presence of complement-fixing antibody to an early herpes simplex virus type 2 (HSV-2) antigen (the AG-4 antigen) was correlated with HSV-2 infection in the sera of patients with genital herpes. Eighty-eight per cent of sera taken two weeks after clinical diagnosis of a primary or recurrent herpes infection in patients, confirmed to have HSV-2 by virus isolation and typing, contained the an...

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Studies on Complement Fixation

It is shown by complement fixation studies with protein antigens and specific immune rabbit sera that the rate of fixation of complement is determined by the concentration of antibodies in the immune sera, that the greater part of fixation of complement takes place during the 1st hour, and that fixation is practically completed at the end of 4 hours at ice box temperature. It is further shown t...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1955

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.70.2.205-215.1955